Here is Chentao LI (李晨涛). I’m currently a PhD student in Bioscience and Biomedical Engineering at The Hong Kong University of Science and Technology (Guangzhou). I have obtained the Bachelor’s degree in Biomedical Sciences from Zhejiang University and the Bachelor’s degree in Integrative Biomedical Sciences from The University of Edinburgh.

My research interests include:

Epigenetics
Immunology

🎓 Educations

2024 - now, PhD, Bioscience and Biomedical Engineering, The Hong Kong University of Science and Technology, China.
2020 - 2024, BSc, Biomedical Sciences, Zhejiang University, China.
2020 - 2024, BSc, Integrative Biomedical Sciences, The University of Edinburgh, United Kingdom.

📝 Publications

For all publications, please refer to my Google profile

† Co-First Author, # Corresponding author

Research

iScience 2024

Li, X.†, Zhang, W.†, Wang, Y.†, Li, C.†, Wu, Y., Shang, Y., Lin, H., Li, Y., Wang, Y., Zeng, X., Cen, Z., Lai, X., Luo, Y.#, Qian, P.#, Huang, H.# (2024). Monocytes in allo-HSCT with aged donors secrete IL-1/IL-6/TNF to increase the risk of GVHD and damage the aged HSCs. iScience. Doi: 10.1016/j.isci.2024.109126. [Link] [PDF]

Summary: We comprehensively reintegrated our clinical data from patients after allo-HSCT and public single-cell transcriptomic profile from post-allo-HSCT and healthy individuals, demonstrating that old donors were more prone to acute GVHD (aGVHD) with pronounced inflammation accumulation and worse overall survival (OS). We also found the presence of inflammation-related CXCL2+ HSC subpopulation during aging with significantly enriched pro-inflammatory pathways. Shifting attention to the HSC microenvironment, we deciphered that IL-1/IL-6 and TRAIL (i.e., TNFSF10) ligand‒receptor pair serves as the crucial bridge between CD14/CD16 monocytes and hematopoietic stem/progenitor cells (HSPCs). The profound upregulation of these signaling pathways during aging finally causes HSC dysfunction and lineage-biased differentiation. Our findings provide the theoretical basis for achieving tailored GVHD management and enhancing allo-HSCT regimens efficacy for aged donors.

IJMS 2025

Xu, S.†, Liu, L.†, Li, C.†, Ren, Y., Zhang, M., Xiang, L., Li, N., Xu, J., Bai, S., Lv, Y. (2025). Correlation Among Psoriasis, Iridocyclitis, and Non-alcoholic Fatty Liver Disease: Insights from Mendelian Randomization and Mediation Analysis. International Journal of Medical Sciences, 22(1), 121-131. Doi: 10.7150/ijms.102369. [Link] [PDF]

Summary: This study highlighted that iridocyclitis was significantly associated with an increased risk of NAFLD and that psoriasis was involved in the mechanism by which iridocyclitis triggered NAFLD, which might offer potential preventive strategies for NAFLD.

Review

STTT 2023

Li, X.†, Li, C.†, Zhang, W.†, Wang, Y.†, Qian, P.#, Huang, H.# (2023). Aging and Inflammation: Signaling Pathways and Intervention Therapies. Signal Transduction and Targeted Therapy. Doi: 10.1038/s41392-023-01502-8. [Link] [PDF]

Summary: Here we discuss inflammaging at the molecular, cellular, organ, and disease levels, and review current aging models, the implications of cutting-edge single cell technologies, as well as anti-aging strategies. Since preventing and alleviating aging-related diseases and improving the overall quality of life are the ultimate goals of aging research, our review highlights the critical features and potential mechanisms of inflammation and aging, along with the latest developments and future directions in aging research, providing a theoretical foundation for novel and practical anti-aging strategies.

IJBS 2024

Lin, H.†, Li, C.†, Zhang, W.†, Wu, B.†, Wang, Y., Wang, S., Wang, D.#, Li, X.#, Huang, H.# (2024). Synthetic Cells and Molecules in Cellular Immunotherapy. International Journal of Biological Sciences. Doi: 10.7150/ijbs.94346. [Link] [PDF]

Summary: This review summarizes the innovative strategies of synthetic cells and molecules currently available in cellular immunotherapies, discusses the limitations, and provides insights into the next generation of cellular immunotherapies.

BEHDP 2022

Li, C.†#, Liu, Z.†, Zhou, Y.† (2022). CAR-T Immunotherapy to Beat Solid Tumors: From Challenges to Improvements. Highlights in Science, Engineering and Technology. Doi: 10.54097/hset.v8i.1110. [Link] [PDF]

Summary: This paper describes CAR-T immunotherapy’s mechanisms, development, and applications and discusses the status, difficulties, solutions, and future directions of treating solid tumors by CAR-T immunotherapy.

🏅 Honors and Awards

2024. 6 Outstanding undergraduate graduates of Zhejiang University. [Certificates]
2022.10 Silver Prize of the International Genetically Engineered Machine Competition (iGEM). [Certificates]

📰 News

2024. 12 📰 Give a poster presentation on COGI 2024. [Poster]
2024. 8 🤑 Became a PhD student in Bioscience and Biomedical Engineering Thrust of Systems Hub at The Hong Kong University of Science and Technology (Guangzhou).
2024. 6 🫡 Graduated from Zhejiang University with the Bachelor’s degree of Biomedical Sciences.
2024. 6 🥳 Was awarded the Bachelor’s degree with Honours of Integrative Biomedical Sciences by The University of Edinburgh.
2024. 5 😍 Published the outcomes of iGEM on IJBS [DOI: 10.7150/ijbs.94346].
2024. 2 😍 Published the first research paper on iScience [DOI: 10.1016/j.isci.2024.109126].
2023. 9 😭 Tried to apply for oversea PhD programs but all applications were all rejected.
2023. 6 😍 Published the first SCI paper on STTT [DOI: 10.1038/s41392-023-01502-8].
2022.10 😀 Led the ZJUintl-China 2022 iGEM team and won the silver prize of iGEM competition.
2022. 8 🙃 Published the first academic paper on BEHDP conference [DOI: 10.54097/hset.v8i.1110].
2021.10 😚 Founded the first iGEM team of Internarional Campus, Zhejiang University - [ZJUintl-China 2022].
2021. 3 🤑 Launched the first research project of Student Research Training Program at Zhejiang University with provincial funding.
2020. 9 😝 Enrolled in the Integrative Biomedical Sciences BSc (Hons) program of The University of Edinburgh.
2020. 9 😜 Enrolled in the Biomedical Sciences BSc program of Zhejiang University.
2020. 7 😱 Participated in the National College Entrance Examination 2020 (deferred due to the COVID-19 epidemic).

💻 Blogs

张杰演唱会

2024.11.09 🎤2024张杰未·LIVE开往1982巡回演唱会（南宁站）- 147 - 和表姐一起！

诺奖得主

2024.11.01 📷与2014年诺贝尔化学奖得主Stefan W. Hell的合影！

Click here to open all my blogs

新疆行

2024.07.14 🌊新疆行·独库公路&独山子大峡谷！

新疆行

2024.07.13 🐏新疆行· 那拉提！

新疆行

2024.07.12 🏔新疆行· 伊昭公路&夏塔！

新疆行

2024.07.11 🌊新疆行· 赛里木湖！

新疆行

2024.07.10 🆒新疆行· 世界魔鬼城！

新疆行

2024.07.09 🤠新疆行· 喀纳斯！

新疆行

2024.07.08 🏕新疆行· 禾木村！

新疆行

2024.07.07 🌊新疆行· 天山天池！

新疆行

2024.07.06 🏙新疆行· 乌鲁木齐！

本科毕业

2024.06.22 🎓️重新介绍一下，我是浙江大学2024届毕业生！

云南行

2024.06.16 🌊云南行 · 洱海！

云南行

2024.06.15 🦌云南行 · 普达措国家公园！

云南行

2024.06.14 🏕云南行 · 独克宗古城！

云南行

2024.06.13 🏔︎云南行 · 玉龙雪山！

本科毕业

2024.06.12 🎓️一张可爱的毕业纪念照！

千岛湖

2024.05.31 🌊毕业进程完结后的度假！

ZJU BSc Dissertation

2024.05.24 😎浙江大学毕业论文提交！

小熊收集计划

2024.05.22 😘浙江大学专属毕业小熊与爱丁堡大学专属毕业小熊！收集成功！

西安行

2024.05.11 🤠西安行，登顶华山南峰，五岳之巅！

西安行

2024.05.10 😉西安行，大唐芙蓉园！

Edin BSc Dissertation

2024.04.23 🫠爱丁堡大学毕业论文提交！

谷歌学术

2024.04.20 👻谷歌被引用次数破百纪念！

本科毕业答辩

2024.04.16 🫢浙江大学&爱丁堡大学本科毕业答辩！

张杰演唱会

2024.04.12 🤗2024张杰未·LIVE开往1982巡回演唱会（南昌站）- 97！

广州行

2023.12.01 🫣广州行，广州塔！

卡片集合

2023.05.26 🫡身份卡集结！

生日快乐

2022.10.17 🥳20岁生日快乐！

浙江大学海宁国际校区

2022.9.15 😎纪念一次浙江大学海宁国际校区的日落。

发癫日常

2022.05.02 🥸收集发癫日常~

发癫日常

2022.04.02 🥸收集发癫日常~

520

2021.05.20 🤓属于我的花~

上海行

2021.04.02 🥸上海行，收集日常~

小熊特辑

2021.03.23 🥸带着小熊一起发癫~

毅行

2020.10.11 😫秋季毅行！

浙江大学海宁国际校区

2020.9.15 😎纪念一次浙江大学海宁国际校区的日落。

📧 Contact

Corresponding Information
lichentao2002@outlook.com
Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Nansha, Guangzhou, 511458, China.